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KMID : 1037120190370030347
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The World Journal of Men′s Health
2019 Volume.37 No. 3 p.347 ~ p.354
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Male Inflammatory Parameters Are not Useful to Predict the Outcomes of Intracytoplasmic Sperm Injection: Results from a Cross-Sectional Study
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Cito Gianmartin
Coccia Maria Elisabetta
Picone Rita
Cocci Andrea
Russo Giorgio Ivan
Cai Tommaso
Bencini Giulia
Fucci Rossella
Micelli Elisabetta
Criscuoli Luciana
Bertocci Francesco
Borrani Elena
Serni Sergio
Carini Marco
Natali Alessandro
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Abstract
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Purpose: The relationship between male systemic inflammation and fertility seems intriguing, but no data about its impact on the assisted reproductive technology outcomes has been reported. Here, we aimed to evaluate the prognostic role of male systemic inflammatory parameters in intracytoplasmic sperm injection (ICSI) outcomes prediction, in couples undergoing an ovum donation program.
Materials and Methods: From January 2016 to December 2017, one hundred-ten couples were considered for this cross-sectional study. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-eosinophil ratio (MER), platelet-to-lymphocyte ratio (PLR), seminal parameters, fertilization rate (FR), cleavage rate (CR), pregnancy rate (PR) were evaluated. Male patients were divided into Group A with FR ≤70%, Group B with FR >70%.
Results: Overall, FR was 74.5%, CR 90.9%, PR 41.8%. Group A included 43 patients, Group B 67 men. Group A showed a median NLR of 1.55, PLR of 106.09, MER of 2.33. Group B reported a median NLR of 1.64, PLR 109.0, MER 2.76. We found no statistically differences between two groups with respect to NLR, PLR, MER (p=0.90, p=0.70, p=0.96, respectively). The age-adjusted linear regression analysis demonstrated only a relationship between NLR and sperm motility count (r=?0.02; p<0.05). Using the univariate logistic regression analysis, we found no significant associations.
Conclusions: We did not find any relationship between ICSI outcomes and male inflammation parameters.
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KEYWORD
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Assisted reproductive techniques, Fertilization, Infertility, Inflammation, Semen analysis, Sperm injections, intracytoplasmic
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